Sorafenib delivery nanoplatform based on superparamagnetic iron oxide nanoparticles magnetically targets hepatocellular carcinoma

Currently,sorafenib is the only systemic therapy capable of increasing overall survival of hepatocellular carcinoma patients.Unfortunately,its side effects,particularly its overall toxicity,limit the therapeutic response that can be achieved.Superparamagnetic iron oxide nanoparticles (SPIONs) are very attractive for drug delivery because they can be targeted to specific sites in the body through application of a magnetic field,thus improving intratumoral accumulation and reducing adverse effects.Here,nanoformulations based on polyethylene glycol modified phospholipid micelles,loaded with both SPIONs and sorafenib,were successfully prepared and thoroughly investigated by complementary techniques.This nanovector system provided effective drug delivery,had an average hydrodynamic diameter of about 125 nm,had good stability in aqueous medium,and allowed controlled drug loading.Magnetic analysis allowed accurate determination of the amount of SPIONs embedded in each micelle.An in vitro system was designed to test whether the SPION micelles can be efficiently held using a magnetic field under typical flow conditions found in the human liver.Human hepatocellular carcinoma (HepG2) cells were selected as an in vitro system to evaluate tumor cell targeting efficacy of the superparamagnetic micelles loaded with sorafenib.These experiments demonstrated that this delivery platform is able to enhance sorafenib's antitumor effectiveness by magnetic targeting.The magnetic nanovectors described here represent promising candidates for targeting specific hepatic tumor sites,where selective release of sorafenib can improve its efficacy and safety profile.     

Do you really mean what you actually enforced?

In their works on the theoretical side of Polymer, Ligatti and his co-authors have identified a new class of enforcement mechanisms based on the notion of edit automata that can transform sequences and enforce more than simple safety properties. We show that there is a gap between the edit automata that one can possibly write (e.g., by Ligatti et?al in their IJIS running example) and the edit automata that are actually constructed according the theorems from Ligatti??s IJIS paper or from Talhi et?al. ??Ligatti??s automata?? are just a particular kind of edit automata. Thus, we re-open a question which seemed to have received a definitive answer: you have written your security enforcement mechanism (aka your edit automata); does it really enforce the security policy you wanted?     

Experimental evaluation of pheromone models in ACOPlan

In this paper the system ACOPlan for planning with non uniform action cost is introduced and analyzed. ACOPlan is a planner based on the ant colony optimization framework, in which a colony of planning ants searches for near optimal solution plans with respect to an overall plan cost metric. This approach is motivated by the strong similarity between the process used by artificial ants to build solutions and the methods used by state?Cbased planners to search solution plans. Planning ants perform a stochastic and heuristic based search by interacting through a pheromone model. The proposed heuristic and pheromone models are presented and compared through systematic experiments on benchmark planning domains. Experiments are also provided to compare the quality of ACOPlan solution plans with respect to state of the art satisficing planners. The analysis of the results confirm the good performance of the Action?CAction pheromone model and points out the promising performance of the novel Fuzzy?CLevel?CAction pheromone model. The analysis also suggests general principles for designing performant pheromone models for planning and further extensions of ACOPlan to other optimization models.     

Knowledge Management in Locating the Patient in an Emergency Medical Service in Italy

This study examines an Emergency Medical Service in order to analyze the composite set of activities and instruments directed at locating the patient. The good management of information about the location of the emergency is highly relevant for a reliable rescue service, but this information depends on knowledge of the territory that is socially distributed between EMS operators and callers. Accordingly, the decision-making process often has to go beyond the emergency service protocols, engaging the operator in undertaking an open negotiation in order to transform the caller’s role from layman to “co-worker”. The patient’s location turns out to be an emerging phenomenon, collaborative work based on knowledge management involving two communities—the callers and the EMS operators—that overlap partially. Drawing examples from emergency calls, the study analyzes the practice of locating a patient as a complex and multi-layered process, highlighting the role played by new and old technologies (the information system and the paper maps) in this activity. We argue that CSCW technologies enable the blended use of different kinds of instruments and support an original interconnection between the professional localization systems and the public’s way of defining a position.     

Product interface design: A participatory approach based on virtual reality

The usability of the user interface is a key aspect for the success of several industrial products. This assumption has led to the introduction of numerous design methodologies addressed to evaluate the user-friendliness of industrial products. Most of these methodologies follow the participatory design approach to involve the user in the design process. Virtual Reality is a valid tool to support Participatory Design, because it facilitates the collaboration among designers and users.The present study aims to evaluate the feasibility and the efficacy of an innovative Participatory Design approach where Virtual Reality plays a ‘double role’: a tool to evaluate the usability of the virtual product interface, and a communication channel that allows users to be directly involved in the design process as co-designers.In order to achieve these goals, we conducted three experiments: the purpose of the first experiment is to determine the influence of the virtual interface on the usability evaluation by comparing “user–real product” interaction and “user–virtual product” interaction. Subsequently, we tested the effectiveness of our approach with two experiments involving users (directly or through their participation in a focus group) in the redesign of a product user interface. The experiments were conducted with two typologies of consumer appliances: a microwave oven and a washing machine.     

A coarse-grain reconfigurable architecture for multimedia applications supporting subword and floating-point calculations

Signal processors exploiting ASIC acceleration suffer from sky-rocketing manufacturing costs and long design cycles. FPGA-based systems provide a programmable alternative for exploiting computation parallelism, but the flexibility they provide is not as high as in processor-oriented architectures: HDL or C-to-HDL flows still require specific expertise and a hardware knowledge background. On the other hand, the large size of the configuration bitstream and the inherent complexity of FPGA devices make their dynamic reconfiguration not a very viable approach. Coarse-grained reconfigurable architectures (CGRAs) are an appealing solution but they pose implementation problems and tend to be application specific. This paper presents a scalable CGRA which eases the implementation of algorithms on field programmable gate array (FPGA) platforms. This design option is based on two levels of programmability: it takes advantage of performance and reliability provided by state-of-the-art FPGA technology, and at the same time it provides the user with flexibility, performance and ease of reconfiguration typical of standard CGRAs. The basic cell template provides advanced features such as sub-word SIMD integer and floating-point computation capabilities, as well as saturating arithmetic. Multiple reconfiguration contexts and partial run-time reconfiguration capabilities are provided, tackling this way the problem of high reconfiguration overhead typical of FPGAs. Selected instances of the proposed architecture have been implemented on an Altera Stratix II EP2S180 FPGA. On this system, we mapped some common DSP, image processing, 3D graphics and audio compression algorithms in order to validate our approach and to demonstrate its effectiveness by benchmarking the benefits achieved.     

A bounded distance metric for comparing tree structure

Comparing tree-structured data for structural similarity is a recurring theme and one on which much effort has been spent. Most approaches so far are grounded, implicitly or explicitly, in algorithmic information theory, being approximations to an information distance derived from Kolmogorov complexity. In this paper we propose a novel complexity metric, also grounded in information theory, but calculated via Shannon's entropy equations. This is used to formulate a directly and efficiently computable metric for the structural difference between unordered trees. The paper explains the derivation of the metric in terms of information theory, and proves the essential property that it is a distance metric. The property of boundedness means that the metric can be used in contexts such as clustering, where second-order comparisons are required. The distance metric property means that the metric can be used in the context of similarity search and metric spaces in general, allowing trees to be indexed and stored within this domain. We are not aware of any other tree similarity metric with these properties.     

The MORPHEUS Heterogeneous Dynamically Reconfigurable Platform

Reconfigurable computing offers a wide range of low cost and efficient solutions for embedded systems. The proper choice of the reconfigurable device, the granularity of its processing elements and its memory architecture highly depend on the type of application and their data flow. Existing solutions either offer fine grain FPGAs, which rely on a hardware synthesis flow and offer the maximum degree of flexibility, or coarser grain solutions, which are usually more suitable for a particular type of data flow and applications. In this paper, we present the MORPHEUS architecture, a versatile reconfigurable heterogeneous System-on-Chip targeting streaming applications. The presented architecture exploits different reconfigurable technologies at several computation granularities that efficiently address the different applications needs. In order to efficiently exploit the presented architecture, we implemented a complete software solution to map C applications to the reconfigurable architecture. In this paper, we describe the complete toolset and provide concrete use cases of the architecture.